Reaction Details Report a problem with these data
Target
Carbonic anhydrase 12
Ligand
BDBM50240179
Substrate
n/a
Meas. Tech.
Inhibition Assay
Ki
7.30±n/a nM
Citation
 Supuran, C; Dedhar, S; McDonald, PC; Carta, F Sulfonamide compounds for inhibition of metastatic tumor growth US Patent  US9962398 Publication Date 5/8/2018 
Target
Name:
Carbonic anhydrase 12
Synonyms:
CA-XII | CA12 | CAH12_HUMAN | Carbonate dehydratase XII | Carbonic anhydrase | Carbonic anhydrase 12 (CA XII) | Carbonic anhydrase XII | Carbonic anhydrase XII (CA XII) | Carbonic anhydrase XII (CAXII) | Tumor antigen HOM-RCC-3.1.3
Type:
Enzyme
Mol. Mass.:
39456.00
Organism:
Homo sapiens (Human)
Description:
Catalytic domain of human cloned isozyme was used in the assay
Residue:
354
Sequence:
MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDLHSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHLHWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQVQVCTAAGLSLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMETEAHA
  
Inhibitor
Name:
BDBM50240179
Synonyms:
CHEMBL1334282 | US9962398, Compound MST-141
Type:
Small organic molecule
Emp. Form.:
C13H12FN3O3S
Mol. Mass.:
309.316
SMILES:
NS(=O)(=O)c1ccc(NC(=O)Nc2ccccc2F)cc1
Structure:
Search PDB for entries with ligand similarity: