Reaction Details Report a problem with these data
Target
Carbonic anhydrase 2
Ligand
BDBM50240174
Substrate
n/a
Meas. Tech.
Inhibition Assay
Ki
0.930±n/a nM
Citation
 Supuran, C; Dedhar, S; McDonald, PC; Carta, F Sulfonamide compounds for inhibition of metastatic tumor growth US Patent  US9962398 Publication Date 5/8/2018 
Target
Name:
Carbonic anhydrase 2
Synonyms:
CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:
Enzyme
Mol. Mass.:
29250.71
Organism:
Homo sapiens (Human)
Description:
P00918
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
  
Inhibitor
Name:
BDBM50240174
Synonyms:
CHEMBL4100248 | US9962398, Compound MST-147
Type:
Small organic molecule
Emp. Form.:
C13H11F2N3O3S
Mol. Mass.:
327.307
SMILES:
NS(=O)(=O)c1ccc(NC(=O)Nc2c(F)cccc2F)cc1
Structure:
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