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Target
Protein Wnt-3a
Ligand
BDBM263577
Substrate
n/a
Meas. Tech.
WNT Pathway Reporter Gene Assay
IC50
70.0±n/a nM
Citation
 An, S Compounds for treatment of cancer US Patent  US9713612 Publication Date 7/25/2017 
Target
Name:
Protein Wnt-3a
Synonyms:
WNT3A | WNT3A_HUMAN
Type:
PROTEIN
Mol. Mass.:
39379.02
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1469237
Residue:
352
Sequence:
MAPLGYFLLLCSLKQALGSYPIWWSLAVGPQYSSLGSQPILCASIPGLVPKQLRFCRNYVEIMPSVAEGIKIGIQECQHQFRGRRWNCTTVHDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTAAICGCSSRHQGSPGKGWKWGGCSEDIEFGGMVSREFADARENRPDARSAMNRHNNEAGRQAIASHMHLKCKCHGLSGSCEVKTCWWSQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRPRYTYFKVPTERDLVYYEASPNFCEPNPETGSFGTRDRTCNVSSHGIDGCDLLCCGRGHNARAERRREKCRCVFHWCCYVSCQECTRVYDVHTCK
  
Inhibitor
Name:
BDBM263577
Synonyms:
N-(4-(2-methylpyridin-4-yl)benzyl)-2-phenylpyrido[4,3-b]pyrazin-5-amine (Compound No. 5) | US10087181, Compound 5 | US10285988, Compound 5 | US9713612, 5
Type:
Small organic molecule
Emp. Form.:
C26H21N5
Mol. Mass.:
403.4784
SMILES:
Cc1cc(ccn1)-c1ccc(CNc2nccc3nc(cnc23)-c2ccccc2)cc1
Structure:
Search PDB for entries with ligand similarity: