Reaction Details Report a problem with these data
Target
Metabotropic glutamate receptor 2
Ligand
BDBM393753
Substrate
n/a
Meas. Tech.
In Vitro GIRK Thallium Flux Assay (2.5 minutes)
EC50
170±n/a nM
Citation
 Cosford, ND; Raveendra-Panickar, D; Sheffler, DJ Metabotropic glutamate receptor negative allosteric modulators (NAMS) and uses thereof US Patent  US9969726 Publication Date 5/15/2018 
Target
Name:
Metabotropic glutamate receptor 2
Synonyms:
GRM2_RAT | Gprc1b | Grm2 | Mglur2
Type:
PROTEIN
Mol. Mass.:
95786.41
Organism:
Rattus norvegicus
Description:
ChEMBL_105034
Residue:
872
Sequence:
MESLLGFLALLLLWGAVAEGPAKKVLTLEGDLVLGGLFPVHQKGGPAEECGPVNEHRGIQRLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRHICPDGSYATHSDAPTAVTGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEKVGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAATQRLNASFTWVASDGWGALESVVAGSERAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWEERFHCSFRQRDCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTHLCDAMRPVNGRRLYKDFVLNVKFDAPFRPADTDDEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTLDTSFIPWASPSAGPLPASRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEYRLDEFTCADCGLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVFVRHNATPVVKASGRELCYILLGGVFLCYCMTFVFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARIFGGAREGAQRPRFISPASQVAICLALISGQLLIVAAWLVVEAPGTGKETAPERREVVTLRCNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGSAAPRASANLGQGSGSQFVPTVCNGREVVDSTTSSL
  
Inhibitor
Name:
BDBM393753
Synonyms:
BDBM437895 | US9969726, Example 43
Type:
Small organic molecule
Emp. Form.:
C18H11FN2OS
Mol. Mass.:
322.356
SMILES:
Fc1cccc(c1)-c1cccc(c1)-c1nsc(n1)-c1ccoc1
Structure:
Search PDB for entries with ligand similarity: