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Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM394054
Substrate
n/a
Meas. Tech.
Kinase Assay
IC50
<0.500±n/a nM
Citation
 Altman, MD; Andresen, BM; Brubaker, JD; Childers, ML; Donofrio, A; Fischmann, T; Gibeau, CR; Kattar, SD; Lesburg, CA; Lim, J; MacLean, JK; Mansoor, UF; Northrup, AB; Sanders, JM; Torres, L Inhibitors of IRAK4 activity US Patent  US9969749 Publication Date 5/15/2018 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM394054
Synonyms:
5-[4-({trans-4-[(2- methoxyethyl)amino]cyclo- hexyl}amino)quinazolin- 6-yl]pyridin-3-ol | US9969749, Example 5-4
Type:
Small organic molecule
Emp. Form.:
C22H27N5O2
Mol. Mass.:
393.4821
SMILES:
COCCN[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)-c1cncc(O)c1 |r,wU:5.4,wD:8.11,(2.69,-8,;4.23,-8,;5,-6.67,;4.23,-5.33,;2.69,-5.33,;1.92,-4,;.39,-4,;-.39,-2.67,;.39,-1.33,;1.92,-1.33,;2.7,-2.67,;-.38,,;-1.92,,;-2.69,-1.33,;-4.23,-1.33,;-5,,;-4.23,1.33,;-5,2.67,;-4.23,4,;-2.69,4,;-1.92,2.67,;-2.69,1.33,;-1.92,5.33,;-2.69,6.67,;-1.92,8,;-.38,8,;.39,6.67,;1.93,6.67,;-.38,5.33,)|
Structure:
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