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Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM394056
Substrate
n/a
Meas. Tech.
Kinase Assay
IC50
<0.500±n/a nM
Citation
 Altman, MD; Andresen, BM; Brubaker, JD; Childers, ML; Donofrio, A; Fischmann, T; Gibeau, CR; Kattar, SD; Lesburg, CA; Lim, J; MacLean, JK; Mansoor, UF; Northrup, AB; Sanders, JM; Torres, L Inhibitors of IRAK4 activity US Patent  US9969749 Publication Date 5/15/2018 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM394056
Synonyms:
5-[4-({trans-4-[(2R,6S)- 2,6-dimethylmorpholin-4- yl]cyclohexyl}amino) quinazolin-6-yl]pyridin-3-ol | US9969749, Example 5-6
Type:
Small organic molecule
Emp. Form.:
C25H31N5O2
Mol. Mass.:
433.5459
SMILES:
C[C@H]1CN(C[C@@H](C)O1)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)-c1cncc(O)c1 |r,wU:8.8,5.5,1.0,wD:11.15,(1.15,-8.67,;1.92,-7.34,;1.15,-6,;1.92,-4.67,;3.46,-4.67,;4.23,-6,;5.78,-6,;3.46,-7.34,;1.15,-3.33,;-.38,-3.33,;-1.16,-2,;-.38,-.67,;1.15,-.67,;1.93,-2,;-1.15,.67,;-2.69,.67,;-3.47,-.67,;-5,-.67,;-5.78,.67,;-5,2,;-5.78,3.33,;-5,4.67,;-3.47,4.67,;-2.69,3.33,;-3.47,2,;-2.69,6,;-3.47,7.34,;-2.69,8.67,;-1.15,8.67,;-.38,7.34,;1.15,7.34,;-1.15,6,)|
Structure:
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