Reaction Details Report a problem with these data
Target
Type-2 angiotensin II receptor
Ligand
BDBM395229
Substrate
n/a
Meas. Tech.
AT2 Receptor Binding Assay
Ki
7.00±n/a nM
Citation
 Brown, J; McCarthy, TD; Naylor, A; Watts, JP Heterocyclic compounds and methods for their use US Patent  US10308628 Publication Date 6/4/2019 
Target
Name:
Type-2 angiotensin II receptor
Synonyms:
AGTR2 | AGTR2_HUMAN | AT2 | Angiotensin II receptor | Angiotensin II type 2 (AT-2) receptor | Angiotensin II, central | Type-2 angiotensin II receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41201.61
Organism:
Homo sapiens (Human)
Description:
Angiotensin II, central 0 0::P50052
Residue:
363
Sequence:
MKGNSTLATTSKNITSGLHFGLVNISGNNESTLNCSQKPSDKHLDAIPILYYIIFVIGFLVNIVVVTLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVFGSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYIVPLVWCMACLSSLPTFYFRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLKTNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALAWMGVINSCEVIAVIDLALPFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRESMSCRKSSSLREMETFVS
  
Inhibitor
Name:
BDBM395229
Synonyms:
US10308628, Compound 1
Type:
Small organic molecule
Emp. Form.:
C30H30F2N2O4
Mol. Mass.:
520.567
SMILES:
COC(=O)[C@@H]1C[C@@H](CCN1C(=O)C(c1ccccc1)c1ccccc1)N1CCCOc2cc(F)c(F)cc12 |r|
Structure:
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