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Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM395300
Substrate
n/a
Meas. Tech.
IRAK4 Kinase Assay
IC50
12.3±n/a nM
Citation
 Bothe, U; Siebeneicher, H; Schmidt, N; Nubbemeyer, R; Bömer, U; Günther, J; Steuber, H; Lange, M; Stegmann, C; Sutter, A; Rausch, A; Friedrich, C; Hauff, P Substituted indazoles, methods for the production thereof, pharmaceutical preparations that contain said new substituted indazoles, and use of said new substituted indazoles to produce drugs US Patent  US10308634 Publication Date 6/4/2019 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM395300
Synonyms:
6-(Difluoromethyl)-N-[6-(2-hydroxypropan-2-yl)-2-(3-hydroxypropyl)-2H-indazol-5-yl]pyridine-2-carboxamide | US10308634, Example 15 | US10793545, Example 15
Type:
Small organic molecule
Emp. Form.:
C20H22F2N4O3
Mol. Mass.:
404.4105
SMILES:
CC(C)(O)c1cc2nn(CCCO)cc2cc1NC(=O)c1cccc(n1)C(F)F
Structure:
Search PDB for entries with ligand similarity: