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Target
Tyrosine-protein phosphatase non-receptor type 11
Ligand
BDBM396027
Substrate
n/a
Meas. Tech.
SHP2 Allosteric Inhibition Assay
IC50
14.0±n/a nM
Citation
 Chen, Z; Fortanet, JG; LaMarche, MJ; Sendzik, M; Tamez, Jr., V; Yu, B Compounds and compositions for inhibiting the activity of SHP2 US Patent  US10308660 Publication Date 6/4/2019 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 11
Synonyms:
3.1.3.48 | PTN11_HUMAN | PTP-1D | PTP-2C | PTP2C | PTPN11 | Protein Tyrosine Phosphatase PPN11/Shp2 | Protein tyrosine phosphatase (PTP) Shp2 | Protein-Tyrosine Phosphatase SHP-2 | Protein-tyrosine phosphatase 1D | Protein-tyrosine phosphatase 2C | SH-PTP2 | SH-PTP3 | SHP-2 | SHP2 | SHPTP2 | Src homology phosphatase 2 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) | Tyrosine-protein phosphatase non-receptor type 11 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (SHP2)
Type:
Protein phosphatase
Mol. Mass.:
68443.59
Organism:
Homo sapiens (Human)
Description:
Q06124
Residue:
593
Sequence:
MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR
  
Inhibitor
Name:
BDBM396027
Synonyms:
US10308660, Example 129
Type:
Small organic molecule
Emp. Form.:
C21H27Cl2N5O
Mol. Mass.:
436.378
SMILES:
C[C@H]1C[C@@H](N)C2(C1)CCN(CC2)c1nc(N)c(-c2cccc(Cl)c2Cl)c(=O)n1C |r,wD:3.3,1.0,(7.32,3.28,;5.79,3.44,;5.02,4.78,;3.51,4.46,;2.42,5.55,;3.35,2.92,;4.76,2.3,;3.35,1.38,;2.02,.61,;.68,1.38,;.68,2.92,;2.02,3.69,;-.65,.61,;-1.98,1.38,;-3.32,.61,;-4.65,1.38,;-3.32,-.93,;-4.65,-1.7,;-5.99,-.93,;-7.32,-1.7,;-7.32,-3.24,;-5.99,-4.01,;-5.99,-5.55,;-4.65,-3.24,;-3.32,-4.01,;-1.98,-1.7,;-1.98,-3.24,;-.65,-.93,;.68,-1.7,)|
Structure:
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