Reaction Details Report a problem with these data
Target
Mu-type opioid receptor
Ligand
BDBM397990
Substrate
n/a
Meas. Tech.
Radioligand dose-displacement Binding Assay
Ki
1016±52.1 nM
Citation
 Tafesse, L 10-substituted morphinan hydantoins US Patent  US9994571 Publication Date 6/12/2018 
Target
Name:
Mu-type opioid receptor
Synonyms:
M-OR-1 | MOP | MOR-1 | MOR1 | MUOR1 | Mu Opioid Receptor | Mu opiate receptor | OPIATE Mu | OPRM1 | OPRM_HUMAN | hMOP | mu-type opioid receptor isoform MOR-1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44789.51
Organism:
Homo sapiens (Human)
Description:
P35372
Residue:
400
Sequence:
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM397990
Synonyms:
US9994571, Compound 14
Type:
Small organic molecule
Emp. Form.:
C22H27N3O5
Mol. Mass.:
413.4669
SMILES:
O[C@H]1[C@H]2N(CC3CC3)CC[C@@]3(C[C@]4(CC[C@@]23O)NC(=O)NC4=O)c2cc(O)ccc12 |r|
Structure:
Search PDB for entries with ligand similarity: