Reaction Details Report a problem with these data
Target
Kappa-type opioid receptor
Ligand
BDBM397991
Substrate
n/a
Meas. Tech.
Radioligand dose-displacement Binding Assay
Ki
2524±707.7 nM
Citation
 Tafesse, L 10-substituted morphinan hydantoins US Patent  US9994571 Publication Date 6/12/2018 
Target
Name:
Kappa-type opioid receptor
Synonyms:
K-OR-1 | KOR-1 | Kappa-opioid receptor (KOR) | Kappa-type opioid receptor (KOPR) | Kappa-type opioid receptor (KOR) | Kappa-type opioid receptor (Kappa) | OPIATE Kappa | OPRK | OPRK1 | OPRK_HUMAN | kappa opioid receptor (KOR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42648.76
Organism:
Homo sapiens (Human)
Description:
P41145
Residue:
380
Sequence:
MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV
  
Inhibitor
Name:
BDBM397991
Synonyms:
US9994571, Compound 15
Type:
Small organic molecule
Emp. Form.:
C22H23N3O6
Mol. Mass.:
425.4345
SMILES:
Oc1ccc2c3c1O[C@H]1[C@]4(CC[C@@]5(O)[C@H](N(CC6CC6)CC[C@]315)C2=O)NC(=O)NC4=O |r|
Structure:
Search PDB for entries with ligand similarity: