Reaction Details Report a problem with these data
Target
Serine/threonine-protein kinase Chk2 [209-531,Q209M]
Ligand
BDBM34063
Substrate
Histone H1
Meas. Tech.
In Vitro Protein Kinase Assay
pH
7.5±n/a
Temperature
303.15±n/a K
IC50
240±n/a nM
Citation
 Jobson, AG; Cardellina, JH; Scudiero, D; Kondapaka, S; Zhang, H; Kim, H; Shoemaker, R; Pommier, Y Identification of a Bis-guanylhydrazone [4,4'-Diacetyldiphenylurea-bis(guanylhydrazone); NSC 109555] as a novel chemotype for inhibition of Chk2 kinase. Mol Pharmacol 72:876-84 (2007) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase Chk2 [209-531,Q209M]
Synonyms:
CDS1 | CHEK2 | CHK2 | CHK2_HUMAN | Checkpoint Kinase (Chk2) | Checkpoint Kinase 2 | RAD53
Type:
Serine/threonine-protein kinase
Mol. Mass.:
36511.81
Organism:
Homo sapiens (Human)
Description:
O96017[209-531,Q209M]
Residue:
323
Sequence:
MSVYPKALRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHPCIIKIKNFFDAEDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQDEDMKRKFQDLLSEENESTALPQVLAQPSTSRKRPREGEAEGAE
  
Inhibitor
Name:
BDBM34063
Synonyms:
DDUG | NSC 109555 | diacetyldiphenylurea bisguanylhydrazone
Type:
Small organic molecule
Emp. Form.:
C19H24N10O
Mol. Mass.:
408.4603
SMILES:
[#6]-[#6](=[#7]\[#7]=[#6](/[#7])-[#7])-c1ccc(-[#7]-[#6](=O)-[#7]-c2ccc(cc2)-[#6](-[#6])=[#7]\[#7]=[#6](/[#7])-[#7])cc1 |w:2.2,23.24|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
Histone H1
Synonyms:
n/a
Type:
Other Protein Type
Mol. Mass.:
358.43
Organism:
Bos taurus (bovine)
Description:
n/a
Residue:
3
Sequence:
NA