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Target
G-protein coupled receptor 6
Ligand
BDBM381944
Substrate
n/a
Meas. Tech.
Inhibition of cAMP Activity of GPR6 In Vitro Assay
EC50
38700±n/a nM
Citation
 Adams, ME; Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Lam, B; Monenschein, H; Reichard, H; Sun, H Pyrazines as modulators of GPR6 US Patent  US10000468 Publication Date 6/19/2018 
Target
Name:
G-protein coupled receptor 6
Synonyms:
G-protein coupled receptor 6 (GPR6) | GPR6 | GPR6_HUMAN | Sphingosine 1-phosphate receptor GPR6
Type:
Protein
Mol. Mass.:
37886.39
Organism:
Homo sapiens (Human)
Description:
P46095
Residue:
362
Sequence:
MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV
  
Inhibitor
Name:
BDBM381944
Synonyms:
US10000468, Example 14 | US10273225, Example 14
Type:
Small organic molecule
Emp. Form.:
C22H25F2N7O
Mol. Mass.:
441.477
SMILES:
CN(C)C(=O)c1nc(NC2CC2)c(nc1C#N)N1CCN(Cc2ccc(F)cc2F)CC1
Structure:
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