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Target
Matrix metalloproteinase-17
Ligand
BDBM400668
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
57000±n/a nM
Citation
 Kamei, N; Sumikawa, Y; Kamimura, D; Todo, S; Yamada, T; Tokuoka, S Pyridone derivative, pharmaceutical containing the same and methods of use thereof US Patent  US10000476 Publication Date 6/19/2018 
Target
Name:
Matrix metalloproteinase-17
Synonyms:
MMP-17 | MMP17 | MMP17_HUMAN | MT-MMP 4 | MT4-MMP | MT4MMP | MTMMP4 | Matrix metalloproteinase 17 | Matrix metalloproteinase-17 | Membrane-type matrix metalloproteinase 4 | Membrane-type-4 matrix metalloproteinase
Type:
PROTEIN
Mol. Mass.:
66652.56
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1433225
Residue:
603
Sequence:
MRRRAARGPGPPPPGPGLSRLPLPLLLLLALGTRGGCAAPAPAPRAEDLSLGVEWLSRFGYLPPADPTTGQLQTQEELSKAITAMQQFGGLEATGILDEATLALMKTPRCSLPDLPVLTQARRRRQAPAPTKWNKRNLSWRVRTFPRDSPLGHDTVRALMYYALKVWSDIAPLNFHEVAGSAADIQIDFSKADHNDGYPFDGPGGTVAHAFFPGHHHTAGDTHFDDDEAWTFRSSDAHGMDLFAVAVHEFGHAIGLSHVAAAHSIMRPYYQGPVGDPLRYGLPYEDKVRVWQLYGVRESVSPTAQPEEPPLLPEPPDNRSSAPPRKDVPHRCSTHFDAVAQIRGEAFFFKGKYFWRLTRDRHLVSLQPAQMHRFWRGLPLHLDSVDAVYERTSDHKIVFFKGDRYWVFKDNNVEEGYPRPVSDFSLPPGGIDAAFSWAHNDRTYFFKDQLYWRYDDHTRHMDPGYPAQSPLWRGVPSTLDDAMRWSDGASYFFRGQEYWKVLDGELEVAPGYPQSTARDWLVCGDSQADGSVAAGVDAAEGPRAPPGQHDQSRSEDGYEVCSCTSGASSPPGAPGPLVAATMLLLLPPLSPGALWTAAQALTL
  
Inhibitor
Name:
BDBM400668
Synonyms:
US10000476, Compound I-27
Type:
Small organic molecule
Emp. Form.:
C17H16ClN3O4
Mol. Mass.:
361.78
SMILES:
COc1ccc(Cl)cc1C1(Cn2cccc(C)c2=O)NC(=O)NC1=O
Structure:
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