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Target
Bcl-2-related protein A1
Ligand
BDBM34165
Substrate
FITC-Ahx-EDIIRNIARHLAQVGDSMDR
Meas. Tech.
HTS discovery of chemical inhibitors of anti-apoptotic protein Bfl-1
pH
7±n/a
Temperature
296.15±n/a K
IC50
>100000±0 nM
Citation
 PubChem, PC HTS discovery of chemical inhibitors of anti-apoptotic protein Bfl-1 PubChem Bioassay (2008)[AID] 
Target
Name:
Bcl-2-related protein A1
Synonyms:
A1 | A1-A | B-cell leukemia/lymphoma 2 related protein A1a | B2LA1_MOUSE | Bcl2a1 | Bcl2a1a | Bfl-1 | Bfl1 | Hemopoietic-specific early response protein | Protein BFL-1
Type:
Apoptosis regulator protein
Mol. Mass.:
19909.74
Organism:
Mus musculus (Mouse)
Description:
gi_11024684
Residue:
172
Sequence:
MAESELMHIHSLAEHYLQYVLQVPAFESAPSQACRVLQRVAFSVQKEVEKNLKSYLDDFHVESIDTARIIFNQVMEKEFEDGIINWGRIVTIFAFGGVLLKKLPQEQIALDVCAYKQVSSFVAEFIMNNTGEWIRQNGGWEDGFIKKFEPKSGWLTFLQMTGQIWEMLFLLK
  
Inhibitor
Name:
BDBM34165
Synonyms:
2-[6-(2-Fluoro-phenyl)-1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-ylsulfanyl]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)-acetamide | 2-[6-(2-fluorophenyl)-1-phenyl-pyrazolo[3,4-d]pyrimidin-4-yl]sulfanyl-N-(1,3,5-trimethylpyrazol-4-yl)ethanamide | 2-[6-(2-fluorophenyl)-1-phenylpyrazolo[3,4-d]pyrimidin-4-yl]sulfanyl-N-(1,3,5-trimethylpyrazol-4-yl)acetamide | 2-[[6-(2-fluorophenyl)-1-phenyl-4-pyrazolo[3,4-d]pyrimidinyl]thio]-N-(1,3,5-trimethyl-4-pyrazolyl)acetamide | 2-[[6-(2-fluorophenyl)-1-phenyl-pyrazolo[3,4-d]pyrimidin-4-yl]thio]-N-(1,3,5-trimethylpyrazol-4-yl)acetamide | MLS000068484 | SMR000008171 | cid_654499
Type:
Small organic molecule
Emp. Form.:
C25H22FN7OS
Mol. Mass.:
487.552
SMILES:
Cc1nn(C)c(C)c1NC(=O)CSc1nc(nc2n(ncc12)-c1ccccc1)-c1ccccc1F
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
FITC-Ahx-EDIIRNIARHLAQVGDSMDR
Synonyms:
FITC-Bid peptide
Type:
fluorescein-labeled peptide
Mol. Mass.:
358.43
Organism:
n/a
Description:
n/a
Residue:
3
Sequence:
NA