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Target
Bcl-2-related protein A1
Ligand
BDBM34172
Substrate
FITC-Ahx-EDIIRNIARHLAQVGDSMDR
Meas. Tech.
HTS discovery of chemical inhibitors of anti-apoptotic protein Bfl-1
pH
7±n/a
Temperature
296.15±n/a K
IC50
2850±0 nM
Citation
 PubChem, PC HTS discovery of chemical inhibitors of anti-apoptotic protein Bfl-1 PubChem Bioassay (2008)[AID] 
Target
Name:
Bcl-2-related protein A1
Synonyms:
A1 | A1-A | B-cell leukemia/lymphoma 2 related protein A1a | B2LA1_MOUSE | Bcl2a1 | Bcl2a1a | Bfl-1 | Bfl1 | Hemopoietic-specific early response protein | Protein BFL-1
Type:
Apoptosis regulator protein
Mol. Mass.:
19909.74
Organism:
Mus musculus (Mouse)
Description:
gi_11024684
Residue:
172
Sequence:
MAESELMHIHSLAEHYLQYVLQVPAFESAPSQACRVLQRVAFSVQKEVEKNLKSYLDDFHVESIDTARIIFNQVMEKEFEDGIINWGRIVTIFAFGGVLLKKLPQEQIALDVCAYKQVSSFVAEFIMNNTGEWIRQNGGWEDGFIKKFEPKSGWLTFLQMTGQIWEMLFLLK
  
Inhibitor
Name:
BDBM34172
Synonyms:
MLS000038673 | N-(5-ethylsulfanyl-1,3,4-thiadiazol-2-yl)-3,3,3-trifluoro-2-(trifluoromethyl)propanamide | N-(5-ethylsulfanyl-1,3,4-thiadiazol-2-yl)-3,3,3-tris(fluoranyl)-2-(trifluoromethyl)propanamide | N-[5-(ethylthio)-1,3,4-thiadiazol-2-yl]-3,3,3-trifluoro-2-(trifluoromethyl)propanamide | N-[5-(ethylthio)-1,3,4-thiadiazol-2-yl]-3,3,3-trifluoro-2-(trifluoromethyl)propionamide | SMR000035641 | cid_659575
Type:
Small organic molecule
Emp. Form.:
C8H7F6N3OS2
Mol. Mass.:
339.281
SMILES:
CCSc1nnc(NC(=O)C(C(F)(F)F)C(F)(F)F)s1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
FITC-Ahx-EDIIRNIARHLAQVGDSMDR
Synonyms:
FITC-Bid peptide
Type:
fluorescein-labeled peptide
Mol. Mass.:
358.43
Organism:
n/a
Description:
n/a
Residue:
3
Sequence:
NA