Reaction Details Report a problem with these data
Target
Bcl-2-related protein A1
Ligand
BDBM34183
Substrate
FITC-Ahx-EDIIRNIARHLAQVGDSMDR
Meas. Tech.
HTS discovery of chemical inhibitors of anti-apoptotic protein Bfl-1
pH
7±n/a
Temperature
296.15±n/a K
IC50
3720±0 nM
Citation
 PubChem, PC HTS discovery of chemical inhibitors of anti-apoptotic protein Bfl-1 PubChem Bioassay (2008)[AID] 
Target
Name:
Bcl-2-related protein A1
Synonyms:
A1 | A1-A | B-cell leukemia/lymphoma 2 related protein A1a | B2LA1_MOUSE | Bcl2a1 | Bcl2a1a | Bfl-1 | Bfl1 | Hemopoietic-specific early response protein | Protein BFL-1
Type:
Apoptosis regulator protein
Mol. Mass.:
19909.74
Organism:
Mus musculus (Mouse)
Description:
gi_11024684
Residue:
172
Sequence:
MAESELMHIHSLAEHYLQYVLQVPAFESAPSQACRVLQRVAFSVQKEVEKNLKSYLDDFHVESIDTARIIFNQVMEKEFEDGIINWGRIVTIFAFGGVLLKKLPQEQIALDVCAYKQVSSFVAEFIMNNTGEWIRQNGGWEDGFIKKFEPKSGWLTFLQMTGQIWEMLFLLK
  
Inhibitor
Name:
BDBM34183
Synonyms:
2-[4-phenyl-6-(trifluoromethyl)pyrimidin-2-yl]sulfonylacetic acid ethyl ester | 2-[[4-phenyl-6-(trifluoromethyl)-2-pyrimidinyl]sulfonyl]acetic acid ethyl ester | MLS000049112 | SMR000074423 | cid_1151859 | ethyl 2-[4-phenyl-6-(trifluoromethyl)pyrimidin-2-yl]sulfonylacetate | ethyl 2-[4-phenyl-6-(trifluoromethyl)pyrimidin-2-yl]sulfonylethanoate | ethyl {[4-phenyl-6-(trifluoromethyl)-2-pyrimidinyl]sulfonyl}acetate
Type:
Small organic molecule
Emp. Form.:
C15H13F3N2O4S
Mol. Mass.:
374.335
SMILES:
CCOC(=O)CS(=O)(=O)c1nc(cc(n1)C(F)(F)F)-c1ccccc1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
FITC-Ahx-EDIIRNIARHLAQVGDSMDR
Synonyms:
FITC-Bid peptide
Type:
fluorescein-labeled peptide
Mol. Mass.:
358.43
Organism:
n/a
Description:
n/a
Residue:
3
Sequence:
NA