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Target
Serine/threonine-protein kinase pim-3
Ligand
BDBM400839
Substrate
n/a
Meas. Tech.
Enzyme Assay
IC50
<10±n/a nM
Citation
 Li, Y; Burns, DM; Feng, H; Huang, T; Mei, S; Pan, J; Ye, H; Zhu, W; Rafalski, M; Wang, A; Xue, C Furo- and thieno-pyridine carboxamide compounds useful as pim kinase inhibitors US Patent  US10000507 Publication Date 6/19/2018 
Target
Name:
Serine/threonine-protein kinase pim-3
Synonyms:
PIM3 | PIM3_HUMAN | Serine/threonine-protein kinase pim-3 (PIM3)
Type:
Protein
Mol. Mass.:
35888.19
Organism:
Homo sapiens (Human)
Description:
Q86V86
Residue:
326
Sequence:
MLLSKFGSLAHLCGPGGVDHLPVKILQPAKADKESFEKAYQVGAVLGSGGFGTVYAGSRIADGLPVAVKHVVKERVTEWGSLGGATVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGFLLVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDLRSGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVCGDIPFEQDEEILRGRLLFRRRVSPECQQLIRWCLSLRPSERPSLDQIAAHPWMLGADGGVPESCDLRLCTLDPDDVASTTSSSESL
  
Inhibitor
Name:
BDBM400839
Synonyms:
2-Amino-N-{5-[(3R)-3-aminopiperidin-1-yl]-1-methyl-1H-pyrazol-4-yl}thieno[3,2-b]pyridine-3-carboxamide | US10000507, Example 3
Type:
Small organic molecule
Emp. Form.:
C17H21N7OS
Mol. Mass.:
371.46
SMILES:
Cn1ncc(NC(=O)c2c(N)sc3cccnc23)c1N1CCC[C@@H](N)C1 |r|
Structure:
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