Reaction Details Report a problem with these data
Target
Cathepsin B
Ligand
BDBM35500
Substrate
Z-Arg-Arg-AMC
Meas. Tech.
Cathepsin B mixture HTS dose-response confirmation
pH
6.8±n/a
Temperature
296.15±n/a K
IC50
4169.72±n/a nM
Citation
 PubChem, PC Cathepsin B mixture HTS dose-response confirmation  PubChem Bioassay (2008)[AID] 
Target
Name:
Cathepsin B
Synonyms:
APP secretase | APPS | CATB_HUMAN | CPSB | CTSB | Cathepsin B heavy chain | Cathepsin B light chain | Cathepsin B1
Type:
Enzyme
Mol. Mass.:
37819.69
Organism:
Homo sapiens (Human)
Description:
gi_63102437
Residue:
339
Sequence:
MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCGTFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSWNTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI
  
Inhibitor
Name:
BDBM35500
Synonyms:
2-(4-chlorophenyl)sulfonyl-4,5-dimethyl-3,6-dihydro-1,2-thiazine 1-oxide | 2-(4-chlorophenyl)sulfonyl-4,5-dimethyl-3,6-dihydrothiazine 1-oxide | MLS000048879 | SMR000061427 | cid_794694
Type:
Small organic molecule
Emp. Form.:
C12H14ClNO3S2
Mol. Mass.:
319.827
SMILES:
CC1=C(C)CS(=O)N(C1)S(=O)(=O)c1ccc(Cl)cc1 |c:1|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
Z-Arg-Arg-AMC
Synonyms:
Benzyloxycarbonyl- L-arginyl- L-arginine- 4-methylcoumaryl-7-amide
Type:
fluorogenic substrate
Mol. Mass.:
358.43
Organism:
n/a
Description:
n/a
Residue:
3
Sequence:
NA