Reaction Details Report a problem with these data
Target
Genome polyprotein [2420-2989,M2842K,R2963Q]
Ligand
BDBM35553
Substrate
poly(A)/oligo(U)18
Meas. Tech.
HCV RNA-Dependent RNA Polymerase Assay (IC50)
pH
7.5±n/a
Temperature
296.15±n/a K
IC50
>1000±n/a nM
Citation
Ontoria, JM; Rydberg, EH; Di Marco, S; Tomei, L; Attenni, B; Malancona, S; Martin Hernando, JI; Gennari, N; Koch, U; Narjes, F; Rowley, M; Summa, V; Carroll, SS; Olsen, DB; De Francesco, R; Altamura, S; Migliaccio, G; Carfì, A Identification and Biological Evaluation of a Series of 1H-Benzo[de]isoquinoline-1,3(2H)-diones as Hepatitis C Virus NS5B Polymerase Inhibitors. J Med Chem 52:5217-27 (2009) [PubMed] Article
More Info.:
Target
Name:
Genome polyprotein [2420-2989,M2842K,R2963Q]
Synonyms:
HCV NS5B Polymerase Mutant (M423K) | POLG_HCVBK
Type:
Mutant Enzyme
Mol. Mass.:
64280.74
Organism:
Hepatitis C virus genotype 1b (isolate BK) (HCV)
Description:
P26663[2420-2989,M2842K,R2963Q]
Residue:
578
Sequence:
SMSYTWTGALITPCAAEESKLPINALSNSLLRHHNMVYATTSRSAGLRQKKVTFDRLQVLDDHYRDVLKEMKAKASTVKAKLLSVEEACKLTPPHSAKSKFGYGAKDVRNLSSKAVNHIHSVWKDLLEDTVTPIDTTIMAKNEVFCVQPEKGGRKPARLIVFPDLGVRVCEKMALYDVVSTLPQVVMGSSYGFQYSPGQRVEFLVNTWKSKKNPMGFSYDTRCFDSTVTENDIRVEESIYQCCDLAPEARQAIKSLTERLYIGGPLTNSKGQNCGYRRCRASGVLTTSCGNTLTCYLKASAACRAAKLQDCTMLVNGDDLVVICESAGTQEDAASLRVFTEAMTRYSAPPGDPPQPEYDLELITSCSSNVSVAHDASGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMYAPTLWARKILMTHFFSILLAQEQLEKALDCQIYGACYSIEPLDLPQIIERLHGLSAFSLHSYSPGEINRVASCLRKLGVPPLRVWRHRARSVRARLLSQGGRAATCGKYLFNWAVKTKLKLTPIPAASQLDLSGWFVAGYSGGDIYHSLSRARPRLEHHHHHH
Inhibitor
Name:
BDBM35553
Synonyms:
1H-benzo[de]isoquinoline-1,3(2H)-dione, 1
Type:
Small organic molecule
Emp. Form.:
C20H15BrN2O3
Mol. Mass.:
411.249
SMILES:
OCCNc1ccc2C(=O)N(C(=O)c3cccc1c23)c1cccc(Br)c1
Substrate
Name:
poly(A)/oligo(U)18
Synonyms:
n/a
Type:
homopolymeric template/primer
Mol. Mass.:
358.43
Organism:
n/a
Description:
UTP/3H-UTP as co-substrate.
Residue:
3
Sequence:
NA