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Target
Histone deacetylase 3/Nuclear receptor corepressor 2 [395-489]
Ligand
BDBM402284
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
1310±n/a nM
Citation
 Ma, H; Wang, Y Histone deacetylase inhibitors and methods for use thereof US Patent  US10011611 Publication Date 7/3/2018 
Target
Name:
Histone deacetylase 3/Nuclear receptor corepressor 2 [395-489]
Synonyms:
HDAC3/NCOR2
Type:
Protein
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 2 components.
Component 1
Name:
Histone deacetylase 3
Synonyms:
HD3 | HDAC3 | HDAC3_HUMAN | Histone deacetylase 3 (HDAC3) | Human HDAC3 | RPD3-2 | SMAP45
Type:
Enzyme
Mol. Mass.:
48829.55
Organism:
Homo sapiens (Human)
Description:
O15379
Residue:
428
Sequence:
MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCRFHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGATQLNNKICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEAFYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVINQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYTVRNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQTIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYSRPEAPNEFYDGDHDNDKESDVEI
  
Component 2
Name:
Nuclear receptor corepressor 2 [395-489]
Synonyms:
CTG26 | NCOR2 | NCOR2_HUMAN | Nuclear receptor corepressor 2 (NCOR2)(aa 395-489)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
11648.02
Organism:
Homo sapiens (Human)
Description:
aa 395-489
Residue:
95
Sequence:
IPPMLYDADQQRIKFINMNGLMADPMKVYKDRQVMNMWSEQEKETFREKFMQHPKNFGLIASFLERKTVAECVLYYYLTKKNENYKSLVRRSYRR
  
Inhibitor
Name:
BDBM402284
Synonyms:
(N-hydroxy-4-((3-oxoisothiazolo[5,4-b]pyridin-2(3H)-yl)methyl)benzamide) | US10011611, RBC-3001-A
Type:
Small organic molecule
Emp. Form.:
C14H11N3O3S
Mol. Mass.:
301.32
SMILES:
ONC(=O)c1ccc(Cn2sc3ncccc3c2=O)cc1
Structure:
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