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Target
Histone deacetylase 9 [604-1066]
Ligand
BDBM50446481
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
12.9±n/a nM
Citation
 Ma, H; Wang, Y Histone deacetylase inhibitors and methods for use thereof US Patent  US10011611 Publication Date 7/3/2018 
Target
Name:
Histone deacetylase 9 [604-1066]
Synonyms:
HDAC7 | HDAC7B | HDAC9 | HDAC9_HUMAN | HDRP | Histone deacetylase 9 (aa 604-1066) | KIAA0744 | MITR
Type:
Enzyme Catalytic Domain
Mol. Mass.:
54194.65
Organism:
Homo sapiens (Human)
Description:
aa 604-1066
Residue:
503
Sequence:
ESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGMDGLEKHRLVSRTHSSPAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRILLGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVVRPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSILYISLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIVKPVAKEFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADGRVVLALEGGHDLTAICDASEACVNALLGNELEPLAEDILHQSPNMNAVISLQKIIEIQSKYWKSVRMVAVPRGCALAGAQLQEETETVSALASLTVDVEQPFAQEDSRTAGEPMEEEPAL
  
Inhibitor
Name:
BDBM50446481
Synonyms:
CHEMBL3110004 | US10011611, TMP269 | US10722597, Compound TMP-269
Type:
Small organic molecule
Emp. Form.:
C25H21F3N4O3S
Mol. Mass.:
514.519
SMILES:
FC(F)(F)c1nc(no1)-c1cccc(c1)C(=O)NCC1(CCOCC1)c1nc(cs1)-c1ccccc1
Structure:
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