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Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM402603
Substrate
n/a
Meas. Tech.
IRAK4 Kinase Assay
IC50
6.00±n/a nM
Citation
 Lim, J; Altman, MD; Brubaker, JD; Gibeau, CR Pyrrolotriazine inhibitors of IRAK4 activity US Patent  US10329295 Publication Date 6/25/2019 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM402603
Synonyms:
2-(1,4-diazepan-1-yl)-N- [3-(difluoromethyl)-1- methyl-1H-pyrazol-4- yl]pyrrolo[2,1- f][1,2,4]triazine-7- carboxamide trifluoroacetate | US10329295, Example 15
Type:
Small organic molecule
Emp. Form.:
C17H20F2N8O
Mol. Mass.:
390.3905
SMILES:
Cn1cc(NC(=O)c2ccc3cnc(nn23)N2CCCNCC2)c(n1)C(F)F
Structure:
Search PDB for entries with ligand similarity: