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Target
G-protein coupled estrogen receptor 1
Ligand
BDBM36491
Substrate
n/a
Meas. Tech.
Competitive Binding Assay
Ki
30±0.0 nM
Citation
 Revankar, CM; Mitchell, HD; Field, AS; Burai, R; Corona, C; Ramesh, C; Sklar, LA; Arterburn, JB; Prossnitz, ER Synthetic estrogen derivatives demonstrate the functionality of intracellular GPR30. ACS Chem Biol 2:536-44 (2007) [PubMed]  Article 
Target
Name:
G-protein coupled estrogen receptor 1
Synonyms:
CEPR | CMKRL2 | DRY12 | G-protein coupled estrogen receptor 1 | G-protein-coupled receptor (GPR30 ) | GPER | GPER1 | GPER1_HUMAN | GPR30
Type:
PROTEIN
Mol. Mass.:
42259.21
Organism:
Homo sapiens (Human)
Description:
ChEMBL_982507
Residue:
375
Sequence:
MDVTSQARGVGLEMYPGTAQPAAPNTTSPELNLSHPLLGTALANGTGELSEHQQYVIGLFLSCLYTIFLFPIGFVGNILILVVNISFREKMTIPDLYFINLAVADLILVADSLIEVFNLHERYYDIAVLCTFMSLFLQVNMYSSVFFLTWMSFDRYIALARAMRCSLFRTKHHARLSCGLIWMASVSATLVPFTAVHLQHTDEACFCFADVREVQWLEVTLGFIVPFAIIGLCYSLIVRVLVRAHRHRGLRPRRQKALRMILAVVLVFFVCWLPENVFISVHLLQRTQPGAAPCKQSFRHAHPLTGHIVNLAAFSNSCLNPLIYSFLGETFRDKLRLYIEQKTNLPALNRFCHAALKAVIPDSTEQSDVRFSSAV
  
Inhibitor
Name:
BDBM36491
Synonyms:
E2-COO-
Type:
Small organic molecule
Emp. Form.:
C27H27O4
Mol. Mass.:
415.5014
SMILES:
C[C@]12CCC3C(CCc4cc(O)ccc34)C1CC[C@@]2(O)C#Cc1cccc(c1)C([O-])=O |r|
Structure:
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