Reaction Details Report a problem with these data
Target
m7GpppX diphosphatase
Ligand
BDBM50232538
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
7.62±0.0 nM
EC50
4.0±0.0 nM
Citation
 Singh, J; Salcius, M; Liu, SW; Staker, BL; Mishra, R; Thurmond, J; Michaud, G; Mattoon, DR; Printen, J; Christensen, J; Bjornsson, JM; Pollok, BA; Kiledjian, M; Stewart, L; Jarecki, J; Gurney, ME DcpS as a therapeutic target for spinal muscular atrophy. ACS Chem Biol 3:711-22 (2008) [PubMed]  Article 
Target
Name:
m7GpppX diphosphatase
Synonyms:
DCPS | DCPS_HUMAN | DCS1 | HINT5 | Scavenger mRNA-decapping enzyme (DcpS)
Type:
Enzyme
Mol. Mass.:
38606.80
Organism:
Homo sapiens (Human)
Description:
Q96C86
Residue:
337
Sequence:
MADAAPQLGKRKRELDVEEAHAASTEEKEAGVGNGTCAPVRLPFSGFRLQKVLRESARDKIIFLHGKVNEASGDGDGEDAVVILEKTPFQVEQVAQLLTGSPELQLQFSNDIYSTYHLFPPRQLNDVKTTVVYPATEKHLQKYLRQDLRLIRETGDDYRNITLPHLESQSLSIQWVYNILDKKAEADRIVFENPDPSDGFVLIPDLKWNQQQLDDLYLIAICHRRGIRSLRDLTPEHLPLLRNILHQGQEAILQRYRMKGDHLRVYLHYLPSYYHLHVHFTALGFEAPGSGVERAHLLAEVIENLECDPRHYQQRTLTFALRADDPLLKLLQEAQQS
  
Inhibitor
Name:
BDBM50232538
Synonyms:
5-((1-(2-fluorobenzyl)piperidin-4-yl)methoxy)quinazoline-2,4-diamine | 5-{[1-(2-fluorobenzyl)piperidin-4-yl]methoxy}quinazoline-2,4-diamine | CHEMBL251429 | D156844
Type:
Small organic molecule
Emp. Form.:
C21H24FN5O
Mol. Mass.:
381.4466
SMILES:
Nc1nc(N)c2c(OCC3CCN(Cc4ccccc4F)CC3)cccc2n1
Structure:
Search PDB for entries with ligand similarity: