Reaction Details Report a problem with these data
Target
m7GpppX diphosphatase
Ligand
BDBM36529
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
339.45±0.0 nM
EC50
2540±0.0 nM
Citation
 Singh, J; Salcius, M; Liu, SW; Staker, BL; Mishra, R; Thurmond, J; Michaud, G; Mattoon, DR; Printen, J; Christensen, J; Bjornsson, JM; Pollok, BA; Kiledjian, M; Stewart, L; Jarecki, J; Gurney, ME DcpS as a therapeutic target for spinal muscular atrophy. ACS Chem Biol 3:711-22 (2008) [PubMed]  Article 
Target
Name:
m7GpppX diphosphatase
Synonyms:
DCPS | DCPS_HUMAN | DCS1 | HINT5 | Scavenger mRNA-decapping enzyme (DcpS)
Type:
Enzyme
Mol. Mass.:
38606.80
Organism:
Homo sapiens (Human)
Description:
Q96C86
Residue:
337
Sequence:
MADAAPQLGKRKRELDVEEAHAASTEEKEAGVGNGTCAPVRLPFSGFRLQKVLRESARDKIIFLHGKVNEASGDGDGEDAVVILEKTPFQVEQVAQLLTGSPELQLQFSNDIYSTYHLFPPRQLNDVKTTVVYPATEKHLQKYLRQDLRLIRETGDDYRNITLPHLESQSLSIQWVYNILDKKAEADRIVFENPDPSDGFVLIPDLKWNQQQLDDLYLIAICHRRGIRSLRDLTPEHLPLLRNILHQGQEAILQRYRMKGDHLRVYLHYLPSYYHLHVHFTALGFEAPGSGVERAHLLAEVIENLECDPRHYQQRTLTFALRADDPLLKLLQEAQQS
  
Inhibitor
Name:
BDBM36529
Synonyms:
D156676
Type:
Small organic molecule
Emp. Form.:
C20H25N7O2S
Mol. Mass.:
427.523
SMILES:
CC(=O)Nc1nc(CN2CCC(COc3cccc4nc(N)nc(N)c34)CC2)cs1
Structure:
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