Reaction Details Report a problem with these data
Target
chymase
Ligand
BDBM88542
Substrate
n/a
Meas. Tech.
Enzymatic Chymase Assay
pH
7.5±n/a
IC50
3.00±n/a nM
Comments
extracted
Citation
 Fürstner, C; Ackerstaff, J; Straub, A; Meier, H; Tinel, H; Zimmermann, K; Zubov, D; Schamberger, J Substituted uracils as chymase inhibitors US Patent  US9695131 Publication Date 7/4/2017 
Target
Name:
chymase
Synonyms:
n/a
Type:
Enzyme
Mol. Mass.:
27507.42
Organism:
Mesocricetus auratus (Golden hamster)
Description:
A0A1U7QTH6
Residue:
247
Sequence:
MLLPALRLLLFLLGSSAEAGKIIGGTECRPHARPYMAYLEIVTPENHLSACSGFLIRRNFVMTAAHCAGRSITVLLGAHNKKVKEDTWQKLEVEKQFPHPKYDDHLVLNDIMLLKLKEKANLTLGVGTLPISAKSNSIPPGRVCRAVGWGRTNVNEPPSDTLQEVKMRILDPQACKHFEDFHQEPQLCVGNPKKIRNVYKGDSGGPLLCAGIAQGIASYVLRNAKPPSVFTRISHYRPWINKILREN
  
Inhibitor
Name:
BDBM88542
Synonyms:
US9695131, 51
Type:
Small organic molecule
Emp. Form.:
C28H26F3N5O6
Mol. Mass.:
585.5311
SMILES:
Cc1c(Cn2c(=O)c(cn(-c3ccc4n(C)c(=O)n(C)c4c3)c2=O)C(=O)NC2(CCC2)C(O)=O)cccc1C(F)(F)F
Structure:
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