Reaction Details Report a problem with these data
Target
Dipeptidase 1
Ligand
BDBM36643
Substrate
n/a
Meas. Tech.
Dehydropeptidase I Assay
pH
7±0
Temperature
310.15±0 K
IC50
1.20e+5± 1.0e+4 nM
Citation
 Toney, JH; Fitzgerald, PM; Grover-Sharma, N; Olson, SH; May, WJ; Sundelof, JG; Vanderwall, DE; Cleary, KA; Grant, SK; Wu, JK; Kozarich, JW; Pompliano, DL; Hammond, GG Antibiotic sensitization using biphenyl tetrazoles as potent inhibitors of Bacteroides fragilis metallo-beta-lactamase. Chem Biol 5:185-96 (1998) [PubMed]  Article 
Target
Name:
Dipeptidase 1
Synonyms:
DPEP1 | DPEP1_HUMAN | Dehydropeptidase-I | Dehydropeptidase-I (DHP-1) | Dipeptidase 1 | MDP | Microsomal dipeptidase | RDP | Renal dipeptidase | hRDP
Type:
Protein
Mol. Mass.:
45670.34
Organism:
Homo sapiens (Human)
Description:
P16444
Residue:
411
Sequence:
MWSGWWLWPLVAVCTADFFRDEAERIMRDSPVIDGHNDLPWQLLDMFNNRLQDERANLTTLAGTHTNIPKLRAGFVGGQFWSVYTPCDTQNKDAVRRTLEQMDVVHRMCRMYPETFLYVTSSAGIRQAFREGKVASLIGVEGGHSIDSSLGVLRALYQLGMRYLTLTHSCNTPWADNWLVDTGDSEPQSQGLSPFGQRVVKELNRLGVLIDLAHVSVATMKATLQLSRAPVIFSHSSAYSVCASRRNVPDDVLRLVKQTDSLVMVNFYNNYISCTNKANLSQVADHLDHIKEVAGARAVGFGGDFDGVPRVPEGLEDVSKYPDLIAELLRRNWTEAEVKGALADNLLRVFEAVEQASNLTQAPEEEPIPLDQLGGSCRTHYGYSSGASSLHRHWGLLLASLAPLVLCLSLL
  
Inhibitor
Name:
BDBM36643
Synonyms:
L-161,189
Type:
Small organic molecule
Emp. Form.:
C26H21N5
Mol. Mass.:
403.4784
SMILES:
C(c1ccc(cc1)-c1ccccc1-c1nnn[nH]1)n1c2C=CCCc2c2ccccc12 |c:23|
Structure:
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