Reaction Details Report a problem with these data
Target
Procathepsin L [114-333,T223A]
Ligand
BDBM36812
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
5.5±0
Temperature
298.15±0 K
IC50
>10000±0.0 nM
Citation
 Bogyo, M; Verhelst, S; Bellingard-Dubouchaud, V; Toba, S; Greenbaum, D Selective targeting of lysosomal cysteine proteases with radiolabeled electrophilic substrate analogs. Chem Biol 7:27-38 (2000) [PubMed]  Article 
Target
Name:
Procathepsin L [114-333,T223A]
Synonyms:
CATL1_HUMAN | CTSL | CTSL1 | Cathepsin L
Type:
Cysteine Protease
Mol. Mass.:
24128.88
Organism:
Homo sapiens (Human)
Description:
P07711[114-333,T223A]
Residue:
220
Sequence:
APRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDAGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
  
Inhibitor
Name:
BDBM36812
Synonyms:
CA-074
Type:
Small organic molecule
Emp. Form.:
C17H29N3O5
Mol. Mass.:
355.4293
SMILES:
CCCNC1OC1C(=O)N[C@@H](C(C)CC)C(=O)N1CCC[C@@H]1C(O)=O |r|
Structure:
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