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Target
Tyrosine-protein kinase Lyn
Ligand
BDBM264417
Substrate
n/a
Meas. Tech.
Kinase Assays
IC50
<100.0±n/a nM
Citation
 Zeng, Q; Faris, M; Mollard, A; Warner, SL; Flynn, GA Multiple kinase pathway inhibitors US Patent  US9714247 Publication Date 7/25/2017 
Target
Name:
Tyrosine-protein kinase Lyn
Synonyms:
JTK8 | LYN | LYN_HUMAN | Lck/Yes-related novel protein tyrosine kinase | Tyrosine-protein kinase Lyn (LYN) | V-yes-1 Yamaguchi sarcoma viral related oncogene homolog | p53Lyn | p56Lyn
Type:
Protein
Mol. Mass.:
58575.92
Organism:
Homo sapiens (Human)
Description:
P07948
Residue:
512
Sequence:
MGCIKSKGKDSLSDDGVDLKTQPVRNTERTIYVRDPTSNKQQRPVPESQLLPGQRFQTKDPEEQGDIVVALYPYDGIHPDDLSFKKGEKMKVLEEHGEWWKAKSLLTKKEGFIPSNYVAKLNTLETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVIKHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQKPWDKDAWEIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEKAEERPTFDYLQSVLDDFYTATEGQYQQQP
  
Inhibitor
Name:
BDBM264417
Synonyms:
US9714247, 139
Type:
Small organic molecule
Emp. Form.:
C31H34F2N6O
Mol. Mass.:
544.6381
SMILES:
CN(C1CCN(C)CC1)c1ccc(Nc2cc3n(C4CCCC4)c(=O)c(cc3cn2)-c2c(F)cccc2F)nc1 |(-5.33,3.88,;-5.33,2.34,;-6.67,1.57,;-6.67,.03,;-8,-.74,;-9.34,.03,;-10.67,-.74,;-9.34,1.57,;-8,2.34,;-4,1.57,;-2.67,2.34,;-1.33,1.57,;-1.33,.03,;,-.74,;1.33,.03,;2.67,-.74,;4,.03,;5.33,-.74,;5.33,-2.28,;4.09,-3.19,;4.56,-4.65,;6.1,-4.65,;6.58,-3.19,;6.67,.03,;8,-.74,;6.67,1.57,;5.33,2.34,;4,1.57,;2.67,2.34,;1.33,1.57,;8,2.34,;9.34,1.57,;9.34,.03,;10.67,2.34,;10.67,3.88,;9.34,4.65,;8,3.88,;6.67,4.65,;-2.67,-.74,;-4,.03,)|
Structure:
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