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Target
cAMP-dependent protein kinase catalytic subunit alpha
Ligand
BDBM50216682
Substrate
n/a
Meas. Tech.
Dose-response biochemical assay for inhibitors of protein kinase A (PKA) activity
IC50
6641±n/a nM
Citation
 PubChem, PC Dose-response biochemical assay for inhibitors of protein kinase A (PKA) activity PubChem Bioassay (2007)[AID] 
Target
Name:
cAMP-dependent protein kinase catalytic subunit alpha
Synonyms:
KAPCA_HUMAN | PKA C-alpha | PKACA | PRKACA | cAMP-dependent protein kinase (PKA) | cAMP-dependent protein kinase catalytic (PKA) | cAMP-dependent protein kinase catalytic subunit alpha | cAMP-dependent protein kinase catalytic subunit alpha (PKA) | cAMP-dependent protein kinase catalytic subunit alpha (PKACA) | cAMP-dependent protein kinase catalytic subunit alpha (PKAc) | cAMP-dependent protein kinase catalytic subunit alpha isoform 1 | cAMP-dependent protein kinase, alpha-catalytic subunit
Type:
Enzyme Catalytic Subunit
Mol. Mass.:
40598.73
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
351
Sequence:
MGNAAAAKKGSEQESVKEFLAKAKEDFLKKWESPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF
  
Inhibitor
Name:
BDBM50216682
Synonyms:
1-(5-Isoquinolinesulfonyl)-2-methylpiperazine | 1-(5-Isoquinolinylsulfonyl)-2-methylpiperazine | 5-(2-methylpiperazine-1-sulfonyl)isoquinoline | CHEMBL323556 | cid_3542
Type:
Small organic molecule
Emp. Form.:
C14H17N3O2S
Mol. Mass.:
291.369
SMILES:
CC1CNCCN1S(=O)(=O)c1cccc2cnccc12
Structure:
Search PDB for entries with ligand similarity: