Reaction Details Report a problem with these data
Target
fMet-Leu-Phe receptor
Ligand
BDBM40411
Substrate
n/a
Meas. Tech.
Formylpeptide Receptor (FPR) Ligand Structure Activity Relationship (SAR) Analysis : Dose Response Assay
IC50
9200±n/a nM
Citation
 PubChem, PC Formylpeptide Receptor (FPR) Ligand Structure Activity Relationship (SAR) Analysis : Dose Response Assay PubChem Bioassay (2007)[AID] 
Target
Name:
fMet-Leu-Phe receptor
Synonyms:
FPR | FPR1 | FPR1_HUMAN | Formyl peptide Receptor | N-formyl peptide receptor 1 | N-formylpeptide chemoattractant receptor | fMLP receptor | fMet-Leu-Phe receptor | formyl peptide receptor 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
38456.14
Organism:
Homo sapiens (Human)
Description:
gi_4503779
Residue:
350
Sequence:
METNSSLPTNISGGTPAVSAGYLFLDIITYLVFAVTFVLGVLGNGLVIWVAGFRMTHTVTTISYLNLAVADFCFTSTLPFFMVRKAMGGHWPFGWFLCKFVFTIVDINLFGSVFLIALIALDRCVCVLHPVWTQNHRTVSLAKKVIIGPWVMALLLTLPVIIRVTTVPGKTGTVACTFNFSPWTNDPKERINVAVAMLTVRGIIRFIIGFSAPMSIVAVSYGLIATKIHKQGLIKSSRPLRVLSFVAAAFFLCWSPYQVVALIATVRIRELLQGMYKEIGIAVDVTSALAFFNSCLNPMLYVFMGQDFRERLIHALPASLERALTEDSTQTSDTATNSTLPSAEVELQAK
  
Inhibitor
Name:
BDBM40411
Synonyms:
(4E)-5-(2,5-dimethoxyphenyl)-4-[hydroxy(phenyl)methylene]-1-(3-pyridyl)pyrrolidine-2,3-quinone | (4E)-5-(2,5-dimethoxyphenyl)-4-[hydroxy(phenyl)methylidene]-1-(3-pyridinyl)pyrrolidine-2,3-dione | (4E)-5-(2,5-dimethoxyphenyl)-4-[hydroxy(phenyl)methylidene]-1-pyridin-3-ylpyrrolidine-2,3-dione | (4E)-5-(2,5-dimethoxyphenyl)-4-[oxidanyl(phenyl)methylidene]-1-pyridin-3-yl-pyrrolidine-2,3-dione | UNM000003538701 | cid_5291451
Type:
Small organic molecule
Emp. Form.:
C24H20N2O5
Mol. Mass.:
416.426
SMILES:
COc1ccc(OC)c(c1)C1C(C(=O)c2ccccc2)C(=O)C(=O)N1c1cccnc1
Structure:
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