Reaction Details Report a problem with these data
Target
Protein phosphatase 1 regulatory subunit 1A
Ligand
BDBM40777
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
14±0.0 nM
Citation
 Wakimoto, T; Matsunaga, S; Takai, A; Fusetani, N Insight into binding of calyculin A to protein phosphatase 1: isolation of hemicalyculin a and chemical transformation of calyculin A. Chem Biol 9:309-19 (2002) [PubMed]  Article 
Target
Name:
Protein phosphatase 1 regulatory subunit 1A
Synonyms:
IPP1 | PPP1R1A | PPR1A_HUMAN | Protein phosphatase 1 regulatory subunit 1A (PP1) | Protein phosphatase inhibitor 1
Type:
Protein
Mol. Mass.:
19010.07
Organism:
Homo sapiens (Human)
Description:
Q13522
Residue:
171
Sequence:
MEQDNSPRKIQFTVPLLEPHLDPEAAEQIRRRRPTPATLVLTSDQSSPEIDEDRIPNPHLKSTLAMSPRQRKKMTRITPTMKELQMMVEHHLGQQQQGEEPEGAAESTGTQESRPPGIPDTEVESRLGTSGTAKKTAECIPKTHERGSKEPSTKEPSTHIPPLDSKGANSV
  
Inhibitor
Name:
BDBM40777
Synonyms:
Hemicalyculin A (5)
Type:
Small organic molecule
Emp. Form.:
C36H55N2O10P
Mol. Mass.:
706.8031
SMILES:
CO[C@@H](C[C@H](O)C(C)[C@H](O)C(C)\C=C(/C)\C(\C)=C\C=C\C(\C)=C\C#N)[C@H]1OC2(C[C@@H](O)[C@H](C)C(C\C=C\C#N)O2)C(C)(C)[C@H]1OP(O)(O)=O |r|
Structure:
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