Reaction Details Report a problem with these data
Target
Protein phosphatase 1 regulatory subunit 1A
Ligand
BDBM40781
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
105±n/a nM
Citation
 Wakimoto, T; Matsunaga, S; Takai, A; Fusetani, N Insight into binding of calyculin A to protein phosphatase 1: isolation of hemicalyculin a and chemical transformation of calyculin A. Chem Biol 9:309-19 (2002) [PubMed]  Article 
Target
Name:
Protein phosphatase 1 regulatory subunit 1A
Synonyms:
IPP1 | PPP1R1A | PPR1A_HUMAN | Protein phosphatase 1 regulatory subunit 1A (PP1) | Protein phosphatase inhibitor 1
Type:
Protein
Mol. Mass.:
19010.07
Organism:
Homo sapiens (Human)
Description:
Q13522
Residue:
171
Sequence:
MEQDNSPRKIQFTVPLLEPHLDPEAAEQIRRRRPTPATLVLTSDQSSPEIDEDRIPNPHLKSTLAMSPRQRKKMTRITPTMKELQMMVEHHLGQQQQGEEPEGAAESTGTQESRPPGIPDTEVESRLGTSGTAKKTAECIPKTHERGSKEPSTKEPSTHIPPLDSKGANSV
  
Inhibitor
Name:
BDBM40781
Synonyms:
Calyculin J (14)
Type:
Small organic molecule
Emp. Form.:
C50H82BrN4O15P
Mol. Mass.:
1090.082
SMILES:
CC[C@H](O)CC1(OCC\C=C\c2coc(n2)C(C)CCNC(=O)[C@@H](O)C(O)[C@H](COC)N(C)C)O[C@H]([C@H](C[C@H](O)C(C)C2OC(C)([C@H](Br)[C@H]2C)C(\C)=C\C=C\C(\C)=C\C#N)OC)[C@H](OP(O)(O)=O)C1(C)C |r|
Structure:
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