Reaction Details Report a problem with these data
Target
Cathepsin B
Ligand
BDBM35507
Substrate
n/a
Meas. Tech.
Cathepsin B dose-response confirmation
IC50
45970.7±5342.3 nM
Citation
 PubChem, PC Cathepsin B dose-response confirmation PubChem Bioassay (2008)[AID] 
Target
Name:
Cathepsin B
Synonyms:
APP secretase | APPS | CATB_HUMAN | CPSB | CTSB | Cathepsin B heavy chain | Cathepsin B light chain | Cathepsin B1
Type:
Enzyme
Mol. Mass.:
37819.69
Organism:
Homo sapiens (Human)
Description:
gi_63102437
Residue:
339
Sequence:
MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCGTFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSWNTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI
  
Inhibitor
Name:
BDBM35507
Synonyms:
4-[1-(3-methoxybenzyl)-1H-benzimidazol-2-yl]-1,2,5-oxadiazol-3-amine | 4-[1-[(3-methoxyphenyl)methyl]-2-benzimidazolyl]-1,2,5-oxadiazol-3-amine | 4-[1-[(3-methoxyphenyl)methyl]benzimidazol-2-yl]-1,2,5-oxadiazol-3-amine | MLS000043676 | SMR000020688 | [4-(1-m-anisylbenzimidazol-2-yl)furazan-3-yl]amine | cid_1506381
Type:
Small organic molecule
Emp. Form.:
C17H15N5O2
Mol. Mass.:
321.3333
SMILES:
COc1cccc(Cn2c(nc3ccccc23)-c2nonc2N)c1
Structure:
Search PDB for entries with ligand similarity: