Reaction Details Report a problem with these data
Target
Sphingosine 1-phosphate receptor 2
Ligand
BDBM41610
Substrate
n/a
Meas. Tech.
Dose Response Cell Based Assay for Antagonists of the S1P2 Receptor
IC50
5199±n/a nM
Citation
 PubChem, PC Dose Response Cell Based Assay for Antagonists of the S1P2 Receptor PubChem Bioassay (2007)[AID] 
Target
Name:
Sphingosine 1-phosphate receptor 2
Synonyms:
EDG5 | S1P2 | S1PR2 | S1PR2_HUMAN | Sphingosine 1-phosphate receptor | Sphingosine 1-phosphate receptor Edg-5 | Sphingosine-1-phosphate receptor 2 | ndothelial differentiation G-protein coupled receptor 5
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
38883.16
Organism:
Homo sapiens (Human)
Description:
Membranes isolated from S1P2-transfected CHO cells were used in ligand binding assay.
Residue:
353
Sequence:
MGSLYSEYLNPNKVQEHYNYTKETLETQETTSRQVASAFIVILCCAIVVENLLVLIAVARNSKFHSAMYLFLGNLAASDLLAGVAFVANTLLSGSVTLRLTPVQWFAREGSAFITLSASVFSLLAIAIERHVAIAKVKLYGSDKSCRMLLLIGASWLISLVLGGLPILGWNCLGHLEACSTVLPLYAKHYVLCVVTIFSIILLAIVALYVRIYCVVRSSHADMAAPQTLALLKTVTIVLGVFIVCWLPAFSILLLDYACPVHSCPILYKAHYFFAVSTLNSLLNPVIYTWRSRDLRREVLRPLQCWRPGVGVQGRRRGGTPGHHLLPLRSSSSLERGMHMPTSPTFLEGNTVV
  
Inhibitor
Name:
BDBM41610
Synonyms:
5-[1-(4-fluorophenyl)-1,2,3,4-tetrazol-5-yl]-2-thiophen-2-yl-4-(trifluoromethyl)pyrimidine | 5-[1-(4-fluorophenyl)-1H-tetraazol-5-yl]-2-(2-thienyl)-4-(trifluoromethyl)pyrimidine | 5-[1-(4-fluorophenyl)-5-tetrazolyl]-2-thiophen-2-yl-4-(trifluoromethyl)pyrimidine | 5-[1-(4-fluorophenyl)tetrazol-5-yl]-2-(2-thienyl)-4-(trifluoromethyl)pyrimidine | 5-[1-(4-fluorophenyl)tetrazol-5-yl]-2-thiophen-2-yl-4-(trifluoromethyl)pyrimidine | MLS000546030 | SMR000163469 | cid_4112227
Type:
Small organic molecule
Emp. Form.:
C16H8F4N6S
Mol. Mass.:
392.334
SMILES:
Fc1ccc(cc1)-n1nnnc1-c1cnc(nc1C(F)(F)F)-c1cccs1
Structure:
Search PDB for entries with ligand similarity: