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Target
Dual specificity protein phosphatase 6
Ligand
BDBM31722
Substrate
n/a
Meas. Tech.
MKP-3 in vitro secondary assay for identification of irreversible and slow-binding inhibitors
IC50
42100±2200 nM
Citation
 PubChem, PC MKP-3 in vitro secondary assay for identification of irreversible and slow-binding inhibitors PubChem Bioassay (2008)[AID] 
Target
Name:
Dual specificity protein phosphatase 6
Synonyms:
DUS6_RAT | Dusp6 | MAP kinase phosphatase 3 | MKP-3 | Mitogen-activated protein kinase phosphatase 3 | Mkp3
Type:
Enzyme
Mol. Mass.:
42303.19
Organism:
Rattus norvegicus
Description:
gi_16758752
Residue:
381
Sequence:
MIDTLRPVPFASEMAISKTVAWLNEQLELGNEQLLLMDCRPQELYESSHIESAINVAIPGIMLRRLQKGNLPVRALFTRCEDRDRFTRRCGTDTVVLYDENSSDWNENTGGESVLGLLLKKLKDEGCRAFYLEGGFSKFQAEFALHCETNLDGSCSSSSPPLPVLGLGGLRISSDSSSDIESDLDRDPNSATDSDGSPLSNSQPSFPVEILPFLYLGCAKDSTNLDVLEEFGIKYILNVTPNLPNLFENAGEFKYKQIPISDHWSQNLSQFFPEAISFIDEARGKNCGVLVHCLAGISRSVTVTVAYLMQKLNLSMNDAYDIVKMKKSNISPNFNFMGQLLDFERTLGLSSPCDNRVPAQQLYFTAPSNQNVYQVDSLQST
  
Inhibitor
Name:
BDBM31722
Synonyms:
2-[[5,6-bis(2-furanyl)-1,2,4-triazin-3-yl]thio]-2,3-dihydroinden-1-one | 2-[[5,6-bis(2-furyl)-1,2,4-triazin-3-yl]thio]indan-1-one | 2-[[5,6-bis(furan-2-yl)-1,2,4-triazin-3-yl]sulfanyl]-2,3-dihydroinden-1-one | MLS-0111566.0001 | cid_6492412
Type:
Small organic molecule
Emp. Form.:
C20H13N3O3S
Mol. Mass.:
375.401
SMILES:
O=C1C(Cc2ccccc12)Sc1nnc(-c2ccco2)c(n1)-c1ccco1
Structure:
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