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Target
Apoptosis regulator Bcl-2
Ligand
BDBM33065
Substrate
n/a
Meas. Tech.
Multiplexed high-throughput screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-2
EC50
6650±n/a nM
Citation
 PubChem, PC Multiplexed high-throughput screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-2 PubChem Bioassay (2008)[AID] 
Target
Name:
Apoptosis regulator Bcl-2
Synonyms:
Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein
Type:
Homodimer or heterodimer
Mol. Mass.:
26269.11
Organism:
Homo sapiens (Human)
Description:
P10415
Residue:
239
Sequence:
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
  
Inhibitor
Name:
BDBM33065
Synonyms:
1-[[2,3-bis(2-furyl)quinoxalin-6-yl]carbamoyl]isonipecotic acid ethyl ester | 1-[[[2,3-bis(2-furanyl)-6-quinoxalinyl]amino]-oxomethyl]-4-piperidinecarboxylic acid ethyl ester | MLS000113285 | SMR000109188 | cid_2925160 | ethyl 1-[[2,3-bis(furan-2-yl)quinoxalin-6-yl]carbamoyl]piperidine-4-carboxylate
Type:
Small organic molecule
Emp. Form.:
C25H24N4O5
Mol. Mass.:
460.4819
SMILES:
CCOC(=O)C1CCN(CC1)C(=O)Nc1ccc2nc(-c3ccco3)c(nc2c1)-c1ccco1
Structure:
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