Reaction Details Report a problem with these data
Target
Cell division control protein 42 homolog
Ligand
BDBM43233
Substrate
n/a
Meas. Tech.
Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 activated mutant
EC50
13940±n/a nM
Citation
 PubChem, PC Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 activated mutant PubChem Bioassay (2010)[AID] 
Target
Name:
Cell division control protein 42 homolog
Synonyms:
CDC42 | CDC42_HUMAN | Cell division control protein 42 homolog | G25K GTP-binding protein | cell division cycle 42 (GTP binding protein, 25kDa)
Type:
PROTEIN
Mol. Mass.:
21258.36
Organism:
Homo sapiens (Human)
Description:
ChEMBL_652970
Residue:
191
Sequence:
MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEITHHCPKTPFLLVGTQIDLRDDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSALTQKGLKNVFDEAILAALEPPEPKKSRRCVLL
  
Inhibitor
Name:
BDBM43233
Synonyms:
1-benzyl-5-chloro-3-methyl-pyrazole-4-carboxylic acid | 1-benzyl-5-chloro-3-methylpyrazole-4-carboxylic acid | 5-chloranyl-3-methyl-1-(phenylmethyl)pyrazole-4-carboxylic acid | 5-chloro-3-methyl-1-(phenylmethyl)-4-pyrazolecarboxylic acid | MLS000759940 | SMR000370104 | cid_2393574
Type:
Small organic molecule
Emp. Form.:
C12H11ClN2O2
Mol. Mass.:
250.681
SMILES:
Cc1nn(Cc2ccccc2)c(Cl)c1C(O)=O
Structure:
Search PDB for entries with ligand similarity: