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Target
Ras-related protein Rab-2A
Ligand
BDBM43258
Substrate
n/a
Meas. Tech.
Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rab2 wildtype
EC50
1990±n/a nM
Citation
 PubChem, PC Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rab2 wildtype PubChem Bioassay (2010)[AID] 
Target
Name:
Ras-related protein Rab-2A
Synonyms:
RAB2 | RAB2A | RAB2A_CANLF | Ras-related protein Rab-2A.
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23545.28
Organism:
Canis lupus familiaris
Description:
gi_46577642
Residue:
212
Sequence:
MAYAYLFKYIIIGDTGVGKSCLLLQFTDKRFQPVHDLTIGVEFGARMITIDGKQIKLQIWDTAGQESFRSITRSYYRGAAGALLVYDITRRDTFNHLTTWLEDARQHSNSNMVIMLIGNKSDLESRREVKKEEGEAFAREHGLIFMETSAKTASNVEEAFINTAKEIYEKIQEGVFDINNEANGIKIGPQHAATNATHAGNQGGQQAGGGCC
  
Inhibitor
Name:
BDBM43258
Synonyms:
2-[(3S,3'aR,8'aS,8'bS)-5,7-dimethyl-1',2,3'-trioxo-2'-spiro[1H-indole-3,4'-3a,6,7,8,8a,8b-hexahydropyrrolo[3,4-a]pyrrolizine]yl]-4,5-dimethyl-3-thiophenecarboxylic acid methyl ester | 2-[(3aR,4S,8aS,8bS)-1,2',3-triketo-5',7'-dimethyl-spiro[3a,6,7,8,8a,8b-hexahydropyrrolo[3,4-a]pyrrolizine-4,3'-indoline]-2-yl]-4,5-dimethyl-thiophene-3-carboxylic acid methyl ester | MLS000580390 | SMR000220594 | cid_16189657 | methyl 2-[(3S,3'aR,8'aS,8'bS)-5,7-dimethyl-1',2,3'-trioxospiro[1H-indole-3,4'-3a,6,7,8,8a,8b-hexahydropyrrolo[3,4-a]pyrrolizine]-2'-yl]-4,5-dimethylthiophene-3-carboxylate | methyl 2-[(3S,3'aR,8'aS,8'bS)-5,7-dimethyl-1',2,3'-tris(oxidanylidene)spiro[1H-indole-3,4'-3a,6,7,8,8a,8b-hexahydropyrrolo[3,4-a]pyrrolizine]-2'-yl]-4,5-dimethyl-thiophene-3-carboxylate
Type:
Small organic molecule
Emp. Form.:
C26H27N3O5S
Mol. Mass.:
493.575
SMILES:
COC(=O)c1c(C)c(C)sc1-n1c(O)c2[C@@H]3CCCN3[C@@]3(C(=O)Nc4c3cc(C)cc4C)c2c1O |wU:20.21,wD:15.20,(4.46,-2.17,;4.46,-.63,;5.79,.14,;7.12,-.63,;5.79,1.68,;4.54,2.58,;3.08,2.11,;5.02,4.05,;4.12,5.29,;6.56,4.05,;7.04,2.58,;8.5,2.11,;9.74,3.01,;9.74,4.55,;10.98,2.11,;12.52,2.11,;13.76,3.01,;15,2.11,;14.53,.65,;13,.65,;11.75,-.26,;10.5,-1.16,;9.04,-.69,;10.98,-2.63,;12.52,-2.63,;13,-1.16,;14.56,-.8,;15.64,-1.99,;17.15,-1.66,;15.15,-3.51,;13.57,-3.84,;13.08,-5.29,;10.5,.65,;8.97,.65,;8.07,-.59,)|
Structure:
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