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Target
Ras-related C3 botulinum toxin substrate 1
Ligand
BDBM43213
Substrate
n/a
Meas. Tech.
Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rac activated mutant
EC50
20560±n/a nM
Citation
 PubChem, PC Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rac activated mutant PubChem Bioassay (2010)[AID] 
Target
Name:
Ras-related C3 botulinum toxin substrate 1
Synonyms:
RAC1_MOUSE | Rac1 | Rac1 protein
Type:
PROTEIN
Mol. Mass.:
21455.91
Organism:
Mus musculus
Description:
EBI_101485
Residue:
192
Sequence:
MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYPEVRHHCPNTPIILVGTKLDLRDDKDTIEKLKEKKLTPITYPQGLAMAKEIGAVKYLECSALTQRGLKTVFDEAIRAVLCPPPVKKRKRKCLLL
  
Inhibitor
Name:
BDBM43213
Synonyms:
3-(2,3-dihydro-1H-indol-1-ylcarbonyl)-N-(4-ethylphenyl)-4-oxo-1,4-dihydroquinoline-6-sulfonamide | 3-(2,3-dihydroindol-1-ylcarbonyl)-N-(4-ethylphenyl)-4-oxidanylidene-1H-quinoline-6-sulfonamide | 3-(2,3-dihydroindole-1-carbonyl)-N-(4-ethylphenyl)-4-oxo-1H-quinoline-6-sulfonamide | 3-[2,3-dihydroindol-1-yl(oxo)methyl]-N-(4-ethylphenyl)-4-oxo-1H-quinoline-6-sulfonamide | MLS000586438 | N-(4-ethylphenyl)-3-(indoline-1-carbonyl)-4-keto-1H-quinoline-6-sulfonamide | SMR000207817 | cid_12004490
Type:
Small organic molecule
Emp. Form.:
C26H23N3O4S
Mol. Mass.:
473.544
SMILES:
CCc1ccc(NS(=O)(=O)c2ccc3ncc(C(=O)N4CCc5ccccc45)c(O)c3c2)cc1
Structure:
Search PDB for entries with ligand similarity: