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Target
E3 ubiquitin-protein ligase Mdm2
Ligand
BDBM43347
Substrate
n/a
Meas. Tech.
E3 Ligase dose-response_384
EC50
15740±n/a nM
Citation
 PubChem, PC E3 Ligase dose-response_384 PubChem Bioassay (2008)[AID] 
Target
Name:
E3 ubiquitin-protein ligase Mdm2
Synonyms:
Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein
Type:
Oncoprotein
Mol. Mass.:
55196.54
Organism:
Homo sapiens (Human)
Description:
Q00987
Residue:
491
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
  
Inhibitor
Name:
BDBM43347
Synonyms:
Adamantane-1-carboxylic acid [6-(cyclopropanecarbonyl-amino)-4-methyl-pyridin-3-yl]-amide | MLS000035082 | N-[6-(cyclopropanecarbonylamino)-4-methyl-3-pyridyl]adamantane-1-carboxamide | N-[6-(cyclopropanecarbonylamino)-4-methylpyridin-3-yl]adamantane-1-carboxamide | N-[6-(cyclopropylcarbonylamino)-4-methyl-pyridin-3-yl]adamantane-1-carboxamide | N-[6-[[cyclopropyl(oxo)methyl]amino]-4-methyl-3-pyridinyl]-1-adamantanecarboxamide | SMR000005533 | cid_655663
Type:
Small organic molecule
Emp. Form.:
C21H27N3O2
Mol. Mass.:
353.458
SMILES:
[H]C12CC3([H])CC([H])(C1)CC(C2)(C3)C(=O)Nc1cnc(NC(=O)C2CC2)cc1C |TLB:8:1:12:6.9.5,8:6:12:1.11.2,THB:5:6:11:3.12.2|
Structure:
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