Reaction Details Report a problem with these data
Target
E3 ubiquitin-protein ligase Mdm2
Ligand
BDBM43349
Substrate
n/a
Meas. Tech.
E3 Ligase dose-response_384
EC50
2960±n/a nM
Citation
 PubChem, PC E3 Ligase dose-response_384 PubChem Bioassay (2008)[AID] 
Target
Name:
E3 ubiquitin-protein ligase Mdm2
Synonyms:
Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein
Type:
Oncoprotein
Mol. Mass.:
55196.54
Organism:
Homo sapiens (Human)
Description:
Q00987
Residue:
491
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
  
Inhibitor
Name:
BDBM43349
Synonyms:
4-[(3,5-dimethyl-1,2-oxazol-4-yl)methoxy]-N-(pyridin-2-ylmethyl)benzamide | 4-[(3,5-dimethyl-4-isoxazolyl)methoxy]-N-(2-pyridinylmethyl)benzamide | 4-[(3,5-dimethylisoxazol-4-yl)methoxy]-N-(2-pyridylmethyl)benzamide | MLS000056151 | SMR000067964 | cid_2495025
Type:
Small organic molecule
Emp. Form.:
C19H19N3O3
Mol. Mass.:
337.3725
SMILES:
Cc1noc(C)c1COc1ccc(cc1)C(=O)NCc1ccccn1
Structure:
Search PDB for entries with ligand similarity: