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Target
E3 ubiquitin-protein ligase Mdm2
Ligand
BDBM43352
Substrate
n/a
Meas. Tech.
E3 Ligase dose-response_384
EC50
11010±n/a nM
Citation
 PubChem, PC E3 Ligase dose-response_384 PubChem Bioassay (2008)[AID] 
Target
Name:
E3 ubiquitin-protein ligase Mdm2
Synonyms:
Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein
Type:
Oncoprotein
Mol. Mass.:
55196.54
Organism:
Homo sapiens (Human)
Description:
Q00987
Residue:
491
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
  
Inhibitor
Name:
BDBM43352
Synonyms:
MLS000048911 | SMR000061449 | [2-[4-(difluoromethoxy)phenyl]-2-oxoethyl] cyclopentanecarboxylate | [2-[4-[bis(fluoranyl)methoxy]phenyl]-2-oxidanylidene-ethyl] cyclopentanecarboxylate | cid_2357650 | cyclopentanecarboxylic acid [2-[4-(difluoromethoxy)phenyl]-2-keto-ethyl] ester | cyclopentanecarboxylic acid [2-[4-(difluoromethoxy)phenyl]-2-oxoethyl] ester
Type:
Small organic molecule
Emp. Form.:
C15H16F2O4
Mol. Mass.:
298.2819
SMILES:
FC(F)Oc1ccc(cc1)C(=O)COC(=O)C1CCCC1
Structure:
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