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Target
E3 ubiquitin-protein ligase Mdm2
Ligand
BDBM43353
Substrate
n/a
Meas. Tech.
E3 Ligase dose-response_384
EC50
47120±n/a nM
Citation
 PubChem, PC E3 Ligase dose-response_384 PubChem Bioassay (2008)[AID] 
Target
Name:
E3 ubiquitin-protein ligase Mdm2
Synonyms:
Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein
Type:
Oncoprotein
Mol. Mass.:
55196.54
Organism:
Homo sapiens (Human)
Description:
Q00987
Residue:
491
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
  
Inhibitor
Name:
BDBM43353
Synonyms:
6-(4-methoxyphenyl)-5-(piperidin-1-ylcarbonyl)-1-(3,4,5-trimethoxyphenyl)piperidin-2-one | 6-(4-methoxyphenyl)-5-(piperidine-1-carbonyl)-1-(3,4,5-trimethoxyphenyl)-2-piperidone | 6-(4-methoxyphenyl)-5-(piperidine-1-carbonyl)-1-(3,4,5-trimethoxyphenyl)piperidin-2-one | 6-(4-methoxyphenyl)-5-[oxo(1-piperidinyl)methyl]-1-(3,4,5-trimethoxyphenyl)-2-piperidinone | 6-(4-methoxyphenyl)-5-piperidin-1-ylcarbonyl-1-(3,4,5-trimethoxyphenyl)piperidin-2-one | MLS000086716 | SMR000022756 | cid_3237621
Type:
Small organic molecule
Emp. Form.:
C27H34N2O6
Mol. Mass.:
482.5687
SMILES:
COc1ccc(cc1)C1C(CCC(=O)N1c1cc(OC)c(OC)c(OC)c1)C(=O)N1CCCCC1
Structure:
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