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Target
E3 ubiquitin-protein ligase Mdm2
Ligand
BDBM43357
Substrate
n/a
Meas. Tech.
E3 Ligase dose-response_384
EC50
2488700±n/a nM
Citation
 PubChem, PC E3 Ligase dose-response_384 PubChem Bioassay (2008)[AID] 
Target
Name:
E3 ubiquitin-protein ligase Mdm2
Synonyms:
Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein
Type:
Oncoprotein
Mol. Mass.:
55196.54
Organism:
Homo sapiens (Human)
Description:
Q00987
Residue:
491
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
  
Inhibitor
Name:
BDBM43357
Synonyms:
2-(2-chlorophenyl)-5-(dimethylamino)-1,3-oxazole-4-carbonitrile | 2-(2-chlorophenyl)-5-(dimethylamino)-4-oxazolecarbonitrile | 2-(2-chlorophenyl)-5-(dimethylamino)oxazole-4-carbonitrile | MLS000062367 | SMR000073011 | cid_891940
Type:
Small organic molecule
Emp. Form.:
C12H10ClN3O
Mol. Mass.:
247.68
SMILES:
CN(C)c1oc(nc1C#N)-c1ccccc1Cl
Structure:
Search PDB for entries with ligand similarity: