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Target
E3 ubiquitin-protein ligase Mdm2
Ligand
BDBM43364
Substrate
n/a
Meas. Tech.
E3 Ligase dose-response_384
EC50
12340±n/a nM
Citation
 PubChem, PC E3 Ligase dose-response_384 PubChem Bioassay (2008)[AID] 
Target
Name:
E3 ubiquitin-protein ligase Mdm2
Synonyms:
Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein
Type:
Oncoprotein
Mol. Mass.:
55196.54
Organism:
Homo sapiens (Human)
Description:
Q00987
Residue:
491
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
  
Inhibitor
Name:
BDBM43364
Synonyms:
1-[2-(4-methoxyphenyl)-5-methyl-3-oxidanyl-imidazol-4-yl]ethanone | 1-[3-Hydroxy-2-(4-methoxy-phenyl)-5-methyl-3H-imidazol-4-yl]-ethanone | 1-[3-hydroxy-2-(4-methoxyphenyl)-5-methyl-4-imidazolyl]ethanone | 1-[3-hydroxy-2-(4-methoxyphenyl)-5-methyl-imidazol-4-yl]ethanone | 1-[3-hydroxy-2-(4-methoxyphenyl)-5-methylimidazol-4-yl]ethanone | MLS000122554 | SMR000119949 | cid_1082694
Type:
Small organic molecule
Emp. Form.:
C13H14N2O3
Mol. Mass.:
246.2619
SMILES:
COc1ccc(cc1)-c1nc(C)c(C(C)=O)n1O
Structure:
Search PDB for entries with ligand similarity: