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Target
E3 ubiquitin-protein ligase Mdm2
Ligand
BDBM43367
Substrate
n/a
Meas. Tech.
E3 Ligase dose-response_384
EC50
1291100±n/a nM
Citation
 PubChem, PC E3 Ligase dose-response_384 PubChem Bioassay (2008)[AID] 
Target
Name:
E3 ubiquitin-protein ligase Mdm2
Synonyms:
Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein
Type:
Oncoprotein
Mol. Mass.:
55196.54
Organism:
Homo sapiens (Human)
Description:
Q00987
Residue:
491
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
  
Inhibitor
Name:
BDBM43367
Synonyms:
(5,6-Dimethyl-benzoimidazol-1-yl)-(4-methyl-piperidin-1-yl)-methanone | (5,6-dimethyl-1-benzimidazolyl)-(4-methyl-1-piperidinyl)methanone | (5,6-dimethylbenzimidazol-1-yl)-(4-methylpiperidin-1-yl)methanone | (5,6-dimethylbenzimidazol-1-yl)-(4-methylpiperidino)methanone | MLS000528358 | SMR000120933 | cid_888939
Type:
Small organic molecule
Emp. Form.:
C16H21N3O
Mol. Mass.:
271.3574
SMILES:
CC1CCN(CC1)C(=O)n1cnc2cc(C)c(C)cc12
Structure:
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