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Target
E3 ubiquitin-protein ligase Mdm2
Ligand
BDBM43374
Substrate
n/a
Meas. Tech.
E3 Ligase dose-response_384
EC50
18680±n/a nM
Citation
 PubChem, PC E3 Ligase dose-response_384 PubChem Bioassay (2008)[AID] 
Target
Name:
E3 ubiquitin-protein ligase Mdm2
Synonyms:
Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein
Type:
Oncoprotein
Mol. Mass.:
55196.54
Organism:
Homo sapiens (Human)
Description:
Q00987
Residue:
491
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
  
Inhibitor
Name:
BDBM43374
Synonyms:
5-Isopropylidene-2-[4-(3-trifluoromethyl-phenyl)-piperazin-1-yl]-thiazol-4-one | 5-isopropylidene-2-[4-[3-(trifluoromethyl)phenyl]piperazino]-2-thiazolin-4-one | 5-propan-2-ylidene-2-[4-[3-(trifluoromethyl)phenyl]-1-piperazinyl]-4-thiazolone | 5-propan-2-ylidene-2-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]-1,3-thiazol-4-one | MLS000558006 | SMR000148722 | cid_2039043
Type:
Small organic molecule
Emp. Form.:
C17H18F3N3OS
Mol. Mass.:
369.405
SMILES:
CC(=C)c1sc(nc1O)N1CCN(CC1)c1cccc(c1)C(F)(F)F
Structure:
Search PDB for entries with ligand similarity: