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Target
E3 ubiquitin-protein ligase Mdm2
Ligand
BDBM43376
Substrate
n/a
Meas. Tech.
E3 Ligase dose-response_384
EC50
12500±n/a nM
Citation
 PubChem, PC E3 Ligase dose-response_384 PubChem Bioassay (2008)[AID] 
Target
Name:
E3 ubiquitin-protein ligase Mdm2
Synonyms:
Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein
Type:
Oncoprotein
Mol. Mass.:
55196.54
Organism:
Homo sapiens (Human)
Description:
Q00987
Residue:
491
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
  
Inhibitor
Name:
BDBM43376
Synonyms:
2-[3-(4-ethyl-1-piperazinyl)-3-oxopropyl]-1H-quinazolin-4-one | 2-[3-(4-ethylpiperazin-1-yl)-3-oxidanylidene-propyl]-1H-quinazolin-4-one | 2-[3-(4-ethylpiperazin-1-yl)-3-oxopropyl]-1H-quinazolin-4-one | 2-[3-(4-ethylpiperazino)-3-keto-propyl]-1H-quinazolin-4-one | MLS000569788 | SMR000155192 | cid_3910366
Type:
Small organic molecule
Emp. Form.:
C17H22N4O2
Mol. Mass.:
314.3822
SMILES:
CCN1CCN(CC1)C(=O)CCc1nc2ccccc2c(=O)[nH]1
Structure:
Search PDB for entries with ligand similarity: